Version 5.4
Mus musculus Protein: Agbl5
Summary
InnateDB Protein IDBP-146373.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agbl5
Protein Name ATP/GTP binding protein-like 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000058564
InnateDB Gene IDBG-146365 (Agbl5)
Protein Structure
UniProt Annotation
Function Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6. {ECO:0000269PubMed:20519502, ECO:0000269PubMed:21074048}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:17244818}. Nucleus {ECO:0000269PubMed:17244818}. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed.
Disease Associations
Tissue Specificity Highly expressed in testis, and moderately in pituitary, brain, eye and kidney. {ECO:0000269PubMed:17244818}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
GO:0015631 tubulin binding
Biological Process
GO:0006508 proteolysis
GO:0035608 protein deglutamylation
GO:0035611 protein branching point deglutamylation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:2441745
InterPro IPR000834 Peptidase M14, carboxypeptidase A
PFAM PF00246
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q09M02
PhosphoSite PhosphoSite-Q09M02
TrEMBL
UniProt Splice Variant
Entrez Gene 231093
UniGene Mm.440364
RefSeq
MGI ID
MGI Symbol Agbl5
OMIM
CCDS
HPRD
IMGT
EMBL AC109606 AK029676 AK034894 AK035680 AK044195 BC057349 DQ867034 DQ867035 DQ867036 DQ867037 DQ867038
GenPept AAH57349 ABI51953 ABI51954 ABI51955 ABI51956 ABI51957 BAC26559 BAC28871 BAC29150 BAC31813

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca