InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sae1

Summary

InnateDB Protein

IDBP-146414.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sae1

Protein Name

SUMO1 activating enzyme subunit 1

Synonyms

2400010M20Rik; 2610044L12Rik; AL033372; AOS1; AW743391; D7Ertd177e; HSPC140; Sua1; Uble1a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092409

InnateDB Gene

IDBG-146412 (Sae1)

Protein Structure

UniProt Annotation

Function

The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Broadly expressed, with highest levels in testis. {ECO:0000269PubMed:11481243}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016874	ligase activity
GO:0019948	SUMO activating enzyme activity
GO:0043008	ATP-dependent protein binding