InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mical1

Summary

InnateDB Protein

IDBP-146517.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mical1

Protein Name

microtubule associated monoxygenase, calponin and LIM domain containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097519

InnateDB Gene

IDBG-146513 (Mical1)

Protein Structure

UniProt Annotation

Function

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. {ECO:0000269PubMed:21730291, ECO:0000269PubMed:23911929}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004497	monooxygenase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0017124	SH3 domain binding
GO:0017137	Rab GTPase binding
GO:0071949	FAD binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0019417	sulfur oxidation
GO:0030042	actin filament depolymerization
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

MGI:2385847

InterPro

IPR001715 Calponin homology domain
IPR001781 Zinc finger, LIM-type
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
IPR022735 Domain of unknown function DUF3585

PFAM

PF00307
PF00412
PF11971
PF12130

PRINTS

PIRSF

SMART

SM00033
SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VDP3