Version 5.4
Mus musculus Protein: Pak1ip1
Summary
InnateDB Protein IDBP-146523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pak1ip1
Protein Name PAK1 interacting protein 1
Synonyms 5830431I15Rik; 5930415H02Rik; AA419825; AI314040; AW556169; Gdpd1; PIP1;
Species Mus musculus
Ensembl Protein ENSMUSP00000040846
InnateDB Gene IDBG-146521 (Pak1ip1)
Protein Structure
UniProt Annotation
Function Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008283 cell proliferation
GO:0009968 negative regulation of signal transduction
GO:0060021 palate development
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1915333
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DCE5
PhosphoSite PhosphoSite-Q9DCE5
TrEMBL Q3UX26
UniProt Splice Variant
Entrez Gene 68083
UniGene Mm.24789
RefSeq NP_080826
MGI ID
MGI Symbol Pak1ip1
OMIM
CCDS CCDS36638
HPRD
IMGT
EMBL AF386076 AK002852 AK077941 AK135946 AK150747 AK150919 AY030406 BC051498
GenPept AAH51498 AAK51599 AAL40652 BAB22407 BAC37076 BAE22737 BAE29818 BAE29957

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca