Version 5.4
Mus musculus Protein: Tti2
Summary
InnateDB Protein IDBP-146567.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tti2
Protein Name cDNA sequence BC019943
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000096441
InnateDB Gene IDBG-146565 (Tti2)
Protein Structure
UniProt Annotation
Function Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:2384576
InterPro IPR016024 Armadillo-type fold
IPR018870 Protein of unknown function DUF2454
PFAM PF10521
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGV4
PhosphoSite PhosphoSite-Q8BGV4
TrEMBL
UniProt Splice Variant
Entrez Gene 234138
UniGene Mm.447990
RefSeq NP_659176
MGI ID
MGI Symbol Tti2
OMIM
CCDS CCDS22221
HPRD
IMGT
EMBL AK045392 AK046031 AK139425 BC019943
GenPept AAH19943 BAC32341 BAC32576 BAE24007

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca