Version 5.4
Mus musculus Protein: Srfbp1
Summary
InnateDB Protein IDBP-146572.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srfbp1
Protein Name serum response factor binding protein 1
Synonyms 2810036K01Rik; p49/STRAP;
Species Mus musculus
Ensembl Protein ENSMUSP00000025406
InnateDB Gene IDBG-146570 (Srfbp1)
Protein Structure
UniProt Annotation
Function May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. {ECO:0000269PubMed:15492011, ECO:0000269PubMed:16647043}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:16647043}.
Disease Associations
Tissue Specificity Highly expressed in heart, skeletal muscle, liver, kidney, testis and brain. Also expressed in white adipose tissue. Expression is up-regulated in cardiomyopathic heart. {ECO:0000269PubMed:15492011, ECO:0000269PubMed:16647043}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1914472
InterPro IPR015158 Bud-site selection protein, BUD22
PFAM PF09073
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CZ91
PhosphoSite PhosphoSite-Q9CZ91
TrEMBL
UniProt Splice Variant
Entrez Gene 67222
UniGene Mm.100617
RefSeq NP_080316
MGI ID
MGI Symbol Srfbp1
OMIM
CCDS CCDS37819
HPRD
IMGT
EMBL AK012865 AK020469 AK141882 AK144845 AK147692 AY611629 BC024338
GenPept AAH24338 AAU25828 BAB28520 BAB32112 BAE24868 BAE26096 BAE28077

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca