InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Emilin1

Summary

InnateDB Protein

IDBP-146578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Emilin1

Protein Name

elastin microfibril interfacer 1

Synonyms

5830419M17Rik; AW229038; BB105748; EMILIN-1; gp115;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031055

InnateDB Gene

IDBG-146576 (Emilin1)

Protein Structure

UniProt Annotation

Function

May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity (By similarity). May have a function in placenta formation and initial organogenesis and a later role in interstitial connective tissue. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030023	extracellular matrix constituent conferring elasticity
GO:0042802	identical protein binding

Biological Process

GO:0007155	cell adhesion
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome