InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sh3bp5

Summary

InnateDB Protein

IDBP-146601.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sh3bp5

Protein Name

SH3-domain binding protein 5 (BTK-associated)

Synonyms

AI606498; Sab; SH3BP-5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098296

InnateDB Gene

IDBG-146595 (Sh3bp5)

Protein Structure

UniProt Annotation

Function

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269PubMed:10339589}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0017124	SH3 domain binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1344391

InterPro

IPR007940 SH3-binding 5

PFAM

PF05276

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z131

PhosphoSite

PhosphoSite-Q9Z131

TrEMBL

UniProt Splice Variant

Entrez Gene

24056

UniGene

Mm.383198

RefSeq

XP_006519076

MGI ID

MGI Symbol

Sh3bp5

OMIM

CCDS

HPRD

IMGT

EMBL

AB016835 AK043375 AK161427 BC018237 BC053741

GenPept

AAH18237 AAH53741 BAA75641 BAC31530 BAE36389