InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNP2

Summary

InnateDB Protein

IDBP-14663.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNP2

Protein Name

transition protein 2 (during histone to protamine replacement)

Synonyms

TP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000325738

InnateDB Gene

IDBG-14661 (TNP2)

Protein Structure

UniProt Annotation

Function

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Expressed by spermatids (at protein level). {ECO:0000269PubMed:9809674}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007339	binding of sperm to zona pellucida
GO:0007340	acrosome reaction
GO:0007341	penetration of zona pellucida
GO:0030154	cell differentiation
GO:0030317	sperm motility