InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Npas1

Summary

InnateDB Protein

IDBP-146631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npas1

Protein Name

neuronal PAS domain protein 1

Synonyms

bHLHe11; MOP5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002053

InnateDB Gene

IDBG-146629 (Npas1)

Protein Structure

UniProt Annotation

Function

May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. {ECO:0000269PubMed:15347806, ECO:0000269PubMed:15635607}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in brain in inhibitory interneurons. Also found in spinal cord. {ECO:0000269PubMed:15347806}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001964	startle response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0042711	maternal behavior