InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmed4

Summary

InnateDB Protein

IDBP-146660.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmed4

Protein Name

transmembrane emp24 protein transport domain containing 4

Synonyms

1110014L17Rik; AI326346;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004508

InnateDB Gene

IDBG-146658 (Tmed4)

Protein Structure

UniProt Annotation

Function

Involved in vesicular protein trafficking, mainly in the early secretory pathway. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:18326488}; Single-pass type I membrane protein {ECO:0000269PubMed:18326488}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity

Biological Process

GO:0006810	transport
GO:0007165	signal transduction
GO:0015031	protein transport
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1915070

InterPro

IPR009038 GOLD

PFAM

PF01105
PF13897

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R1V4

PhosphoSite

PhosphoSite-Q8R1V4

TrEMBL

UniProt Splice Variant

Entrez Gene

103694

UniGene

Mm.471082

RefSeq

NP_598781

MGI ID

MGI Symbol

Tmed4

OMIM

CCDS

CCDS24415

HPRD

IMGT

EMBL

AF368921 AK078425 AK158876 AL607152 BC023041

GenPept

AAH23041 AAM20821 BAC37268 BAE34708 CAI24400