Version 5.4
Mus musculus Protein: Fcna
Summary
InnateDB Protein IDBP-146782.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fcna
Protein Name ficolin A
Synonyms Fcn1;
Species Mus musculus
Ensembl Protein ENSMUSP00000028307
InnateDB Gene IDBG-146780 (Fcna)
Protein Structure
UniProt Annotation
Function Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity). {ECO:0000250}.
Subcellular Localization Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in liver and spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
GO:0097367 carbohydrate derivative binding
Biological Process
GO:0001867 complement activation, lectin pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
Protein Structure and Domains
PDB ID MGI:1340905
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008160 Collagen triple helix repeat
PFAM PF00147
PF01391
PRINTS
PIRSF
SMART SM00186
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O70165
PhosphoSite PhosphoSite-O70165
TrEMBL Q4FJM1
UniProt Splice Variant
Entrez Gene 14133
UniGene Mm.10510
RefSeq NP_032021
MGI ID
MGI Symbol Fcna
OMIM
CCDS CCDS15785
HPRD
IMGT
EMBL AB007813 AK133539 AK138752 AK159651 BC019180 CH466542 CT010383
GenPept AAH19180 BAA25126 BAE21714 BAE23769 BAE35262 CAJ18590 EDL08268

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca