Version 5.4
Mus musculus Protein: Mmgt1
Summary
InnateDB Protein IDBP-146788.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mmgt1
Protein Name membrane magnesium transporter 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000051621
InnateDB Gene IDBG-146786 (Mmgt1)
Protein Structure
UniProt Annotation
Function Mediates Mg(2+) transport. {ECO:0000269PubMed:18057121}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000269PubMed:18057121}; Single- pass type I membrane protein {ECO:0000269PubMed:18057121}. Early endosome membrane {ECO:0000269PubMed:18057121}; Single-pass type I membrane protein {ECO:0000269PubMed:18057121}. Note=Detected in the Golgi apparatus and in post-Golgi vesicles including early endosomes.
Disease Associations
Tissue Specificity Abundant in heart muscle and kidney with lower levels in liver and brain and very little expression in intestine or colon. In kidney, highest levels in distal convoluted tubule. {ECO:0000269PubMed:18057121}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015087 cobalt ion transmembrane transporter activity
GO:0015093 ferrous iron transmembrane transporter activity
GO:0015095 magnesium ion transmembrane transporter activity
GO:0022890 inorganic cation transmembrane transporter activity
Biological Process
GO:0006812 cation transport
GO:0006824 cobalt ion transport
GO:0006825 copper ion transport
GO:0015684 ferrous iron transport
GO:0015693 magnesium ion transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031901 early endosome membrane
GO:0072546 ER membrane protein complex
Protein Structure and Domains
PDB ID MGI:2384305
InterPro IPR018937 Magnesium transporter
PFAM PF10270
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K273
PhosphoSite PhosphoSite-Q8K273
TrEMBL
UniProt Splice Variant
Entrez Gene 236792
UniGene Mm.474780
RefSeq NP_666346
MGI ID
MGI Symbol Mmgt1
OMIM
CCDS CCDS30147
HPRD
IMGT
EMBL AK036253 AK043524 AK049689 BC032271 EU069461
GenPept AAH32271 ABS87351 BAC29362 BAC31567 BAC33874

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca