InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Murc

Summary

InnateDB Protein

IDBP-146802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Murc

Protein Name

muscle-related coiled-coil protein

Synonyms

2310039E09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030033

InnateDB Gene

IDBG-146800 (Murc)

Protein Structure

UniProt Annotation

Function

Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway. {ECO:0000269PubMed:18332105}.

Subcellular Localization

Cytoplasm, myofibril, sarcomere {ECO:0000269PubMed:18332105}. Cytoplasm {ECO:0000269PubMed:18332105}. Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm.

Disease Associations

Tissue Specificity

Abundantly expressed in heart and skeletal muscle with weaker expression in aorta and lung. In heart, expressed in cardiomyocytes and vascular smooth muscle cells but not in other surrounding cells including vascular endothelial cells. {ECO:0000269PubMed:18332105}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007266	Rho protein signal transduction
GO:0007517	muscle organ development
GO:0032321	positive regulation of Rho GTPase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055003	cardiac myofibril assembly