InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elovl2

Summary

InnateDB Protein

IDBP-146870.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elovl2

Protein Name

elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2

Synonyms

AI317360; Ssc2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021793

InnateDB Gene

IDBG-146868 (Elovl2)

Protein Structure

UniProt Annotation

Function

Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (n-6 and n-3 C18-, C20- and C22-PUFA). Essential for the formation of C24:5(n-6) up to C30:5(n-6) PUFAs in testis, these fatty acids being indispensable for normal spermatogenesis and fertility. {ECO:0000269PubMed:12371743, ECO:0000269PubMed:21106902}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in testis, lower level in liver. Weakly expressed in white adipose tissue, brain and kidney. {ECO:0000269PubMed:10791983, ECO:0000269PubMed:12371743}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0009922	fatty acid elongase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0006636	unsaturated fatty acid biosynthetic process
GO:0034626	fatty acid elongation, polyunsaturated fatty acid
GO:0042761	very long-chain fatty acid biosynthetic process