InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snx2

Summary

InnateDB Protein

IDBP-146885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snx2

Protein Name

sorting nexin 2

Synonyms

0610030A03Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039243

InnateDB Gene

IDBG-146883 (Snx2)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). {ECO:0000250}.

Subcellular Localization

Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006897	endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0010008	endosome membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030904	retromer complex
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome