InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tcf23

Summary

InnateDB Protein

IDBP-146888.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcf23

Protein Name

transcription factor 23

Synonyms

2010002O16Rik; bHLHa24; Out;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006818

InnateDB Gene

IDBG-146886 (Tcf23)

Protein Structure

UniProt Annotation

Function

Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis. {ECO:0000269PubMed:10652346}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:10652346}.

Disease Associations

Tissue Specificity

Highly expressed in the uterus (predominantly in myometrium), ovary, and testis. Expression in the uterus is higher in the diestrus phase than in the estrus phase and reaches a maximum at 7.5 dpc. Expression declines towards the time of delivery and returns to the non-pregnant level 4 days after delivery. Low expression seen in lung, heart, intestine, and spleen. {ECO:0000269PubMed:10652346}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046983	protein dimerization activity

Biological Process

GO:0007517	muscle organ development
GO:0030154	cell differentiation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1934960

InterPro

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

PFAM

PF00010

PRINTS

PIRSF

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JLR5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

69852

UniGene

Mm.57874

RefSeq

NP_444315

MGI ID

MGI Symbol

Tcf23

OMIM

CCDS

CCDS19168

HPRD

IMGT

EMBL

AB059397 AF142405 AK030277 AK030297 BC119346 BC120609

GenPept

AAF31168 AAI19347 AAI20610 BAB69473 BAC26873 BAC26885