InnateDB Protein
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IDBP-14689.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SUB1
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Protein Name
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SUB1 homolog (S. cerevisiae)
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Synonyms
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p14; P15; PC4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000265073
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InnateDB Gene
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IDBG-14687 (SUB1)
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Protein Structure
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Function |
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). {ECO:0000269PubMed:16605275, ECO:0000269PubMed:16689930, ECO:0000269PubMed:7628453, ECO:0000269PubMed:8062391, ECO:0000269PubMed:8062392, ECO:0000269PubMed:9360603, ECO:0000269PubMed:9482861}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
42
[view]
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Protein-Protein |
39
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001205
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RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003697
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single-stranded DNA binding
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GO:0003713
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transcription coactivator activity
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GO:0005515
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protein binding
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GO:0044822
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poly(A) RNA binding
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR003173
Transcriptional coactivator p15 (PC4)
IPR009044
ssDNA-binding transcriptional regulator
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PFAM |
PF02229
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P53999
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PhosphoSite |
PhosphoSite-P53999
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TrEMBL |
Q6IBA2
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UniProt Splice Variant |
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Entrez Gene |
10923
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UniGene |
Hs.644972
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RefSeq |
NP_006704
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HUGO |
HGNC:19985
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OMIM |
600503
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CCDS |
CCDS3897
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HPRD |
02737
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IMGT |
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EMBL |
AB209285
AC074134
AK311754
BC009610
BC010537
BC018189
BC022339
BC105972
CH471118
CR456902
U12979
X79805
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GenPept |
AAA20980
AAH09610
AAH10537
AAH18189
AAH22339
AAI05973
BAD92522
BAG34697
CAA56200
CAG33183
EAX10793
EAX10794
EAX10795
EAX10796
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