InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hacl1

Summary

InnateDB Protein

IDBP-146900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hacl1

Protein Name

2-hydroxyacyl-CoA lyase 1

Synonyms

1600020H07Rik; Hpcl; Phyh2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022437

InnateDB Gene

IDBG-146898 (Hacl1)

Protein Structure

UniProt Annotation

Function

Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0005102	receptor binding
GO:0016829	lyase activity
GO:0016830	carbon-carbon lyase activity
GO:0030976	thiamine pyrophosphate binding
GO:0042802	identical protein binding
GO:0048037	cofactor binding

Biological Process

GO:0001561	fatty acid alpha-oxidation
GO:0006629	lipid metabolic process
GO:0051259	protein oligomerization

Cellular Component

GO:0005777

peroxisome

Protein Structure and Domains

PDB ID

MGI:1929657

InterPro

IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding
IPR012000 Thiamine pyrophosphate enzyme, central domain
IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
IPR029035 DHS-like NAD/FAD-binding domain
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF02775
PF00205
PF02776

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QXE0

PhosphoSite