InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fkrp

Summary

InnateDB Protein

IDBP-146930.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fkrp

Protein Name

fukutin related protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059091

InnateDB Gene

IDBG-146928 (Fkrp)

Protein Structure

UniProt Annotation

Function

Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1).

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Secreted. Cell membrane, sarcolemma. Rough endoplasmic reticulum {ECO:0000250}. Note=According to PubMed:19900540 the N-terminal hydrophobic domain is cleaved after translocation to the Golgi apparatus and the protein is secreted. Localization at the cell membrane may require the presence of dystroglycan. At the Golgi apparatus localizes to the middle-to-trans-cisternae. Detected in rough endoplasmic reticulum in myocytes.

Disease Associations

Tissue Specificity

Expressed at highest levels in brain, lung, heart, kidney and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016740	transferase activity

Biological Process

GO:0009101	glycoprotein biosynthetic process
GO:0016485	protein processing

Cellular Component

GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016021	integral component of membrane
GO:0042383	sarcolemma