InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmyc

Summary

InnateDB Protein

IDBP-147084.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmyc

Protein Name

brain expressed myelocytomatosis oncogene

Synonyms

2900002K07Rik; AW060705; Mycb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097885

InnateDB Gene

IDBG-147082 (Bmyc)

Protein Structure

UniProt Annotation

Function

Seems to act as an inhibitor of cellular proliferation. {ECO:0000269PubMed:11039906}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11039906}.

Disease Associations

Tissue Specificity

Highly expressed in epididymis. Also expressed in hypothalamus, pituitary, uterus and ovary. Low expression in testis. Not detected in heart. {ECO:0000269PubMed:11039906}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0070491	repressing transcription factor binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006879	cellular iron ion homeostasis
GO:0006974	cellular response to DNA damage stimulus
GO:0007050	cell cycle arrest
GO:0010332	response to gamma radiation
GO:0032204	regulation of telomere maintenance
GO:0034644	cellular response to UV
GO:0035690	cellular response to drug
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045656	negative regulation of monocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048147	negative regulation of fibroblast proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051782	negative regulation of cell division
GO:0060070	canonical Wnt signaling pathway
GO:2000573	positive regulation of DNA biosynthetic process
GO:2001022	positive regulation of response to DNA damage stimulus