InnateDB Protein
|
IDBP-147089.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Phactr1
|
Protein Name
|
phosphatase and actin regulator 1
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000066663
|
InnateDB Gene
|
IDBG-147085 (Phactr1)
|
Protein Structure
|
|
Function |
Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival (By similarity). Plays a role in cell motility. {ECO:0000250, ECO:0000269PubMed:22976292, ECO:0000269PubMed:23041370}.
|
Subcellular Localization |
Cytoplasm. Cell junction, synapse {ECO:0000250}. Nucleus. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2659021
|
InterPro |
IPR004018
RPEL repeat
|
PFAM |
PF02755
|
PRINTS |
|
PIRSF |
|
SMART |
SM00707
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q2M3X8
|
PhosphoSite |
PhosphoSite-Q2M3X8
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
218194
|
UniGene |
Mm.489126
|
RefSeq |
|
MGI ID |
4B1Z
|
MGI Symbol |
Phactr1
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
AC140415
AC154505
AC164878
AK048208
AY993932
BC048407
BC061691
CH466546
CT025549
|
GenPept |
AAH48407
AAH61691
AAY42814
BAC33272
CAO78135
CAO78137
CAO78138
EDL40986
|
|
|