InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab26

Summary

InnateDB Protein

IDBP-147106.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab26

Protein Name

RAB26, member RAS oncogene family

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046089

InnateDB Gene

IDBG-249850 (Rab26)

Protein Structure

UniProt Annotation

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland. {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305PubMed:20038531}; Lipid-anchor {ECO:0000305PubMed:20038531}; Cytoplasmic side {ECO:0000305PubMed:20038531}. Golgi apparatus membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in zymogenic cells in the stomach. {ECO:0000269PubMed:20038531}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019002	GMP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0017157	regulation of exocytosis
GO:0035272	exocrine system development
GO:0043001	Golgi to plasma membrane protein transport
GO:0045055	regulated secretory pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030658	transport vesicle membrane
GO:0030667	secretory granule membrane
GO:0031226	intrinsic component of plasma membrane

Protein Structure and Domains

PDB ID

MGI:2443284

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670
PF08477

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173
SM00177

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt