Version 5.4
Mus musculus Protein: Cep120
Summary
InnateDB Protein IDBP-147109.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cep120
Protein Name centrosomal protein 120
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000062433
InnateDB Gene IDBG-147107 (Cep120)
Protein Structure
UniProt Annotation
Function Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis. {ECO:0000269PubMed:17920017, ECO:0000269PubMed:20360068}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:17920017}. Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in brain, lung and kidney and weakly expressed in heart, liver, small intestine and limb (at protein level). Expressed in brain. {ECO:0000269PubMed:17920017}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0008283 cell proliferation
GO:0021987 cerebral cortex development
GO:0022008 neurogenesis
GO:0022027 interkinetic nuclear migration
GO:0030953 astral microtubule organization
GO:0032880 regulation of protein localization
GO:0032886 regulation of microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
Protein Structure and Domains
PDB ID MGI:2147298
InterPro IPR000008 C2 domain
IPR022136 Domain of unknown function DUF3668
PFAM PF00168
PF12416
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TSG1
PhosphoSite PhosphoSite-Q7TSG1
TrEMBL
UniProt Splice Variant
Entrez Gene 225523
UniGene Mm.397605
RefSeq NP_848801
MGI ID
MGI Symbol Cep120
OMIM
CCDS CCDS37822
HPRD
IMGT
EMBL AK038916 AK044808 AK044952 AK047594 AK079319 BC046493 BC048590 BC053439
GenPept AAH46493 AAH48590 AAH53439 BAC30167 BAC32100 BAC32156 BAC33092 BAC37606

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca