InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: St3gal1

Summary

InnateDB Protein

IDBP-147120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

St3gal1

Protein Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

Synonyms

5330418N22Rik; AI467004; Siat4; Siat4a; St3gal-1; ST3GalI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090307

InnateDB Gene

IDBG-147118 (St3gal1)

Protein Structure

UniProt Annotation

Function

It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O- linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.

Disease Associations

Tissue Specificity

Highly expressed in submaxillary gland and to a much lesser extent in liver, lung, kidney, heart and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0008373	sialyltransferase activity

Biological Process

GO:0006054	N-acetylneuraminate metabolic process
GO:0006468	protein phosphorylation
GO:0006486	protein glycosylation
GO:0006487	protein N-linked glycosylation
GO:0097503	sialylation

Cellular Component

GO:0005576	extracellular region
GO:0016020	membrane
GO:0030173	integral component of Golgi membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome