Version 5.4
Mus musculus Protein: Chst10
Summary
InnateDB Protein IDBP-147141.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chst10
Protein Name carbohydrate sulfotransferase 10
Synonyms AI507003; AU041319; Hnk-1st; ST;
Species Mus musculus
Ensembl Protein ENSMUSP00000027249
InnateDB Gene IDBG-147139 (Chst10)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. {ECO:0000269PubMed:12213450, ECO:0000269PubMed:12358771}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0016232 HNK-1 sulfotransferase activity
Biological Process
GO:0007612 learning
GO:0007616 long-term memory
GO:0016051 carbohydrate biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2138283
InterPro IPR005331 Sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF03567
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PGK7
PhosphoSite PhosphoSite-
TrEMBL A2RSS2
UniProt Splice Variant
Entrez Gene 98388
UniGene Mm.406869
RefSeq NP_660124
MGI ID
MGI Symbol Chst10
OMIM
CCDS CCDS14901
HPRD
IMGT
EMBL AC101277 AC124699 AF360543 AK046415 AK047378 AK050676 BC026960 BC056956 BC132223 BC132225 CH466536
GenPept AAH26960 AAI32224 AAI32226 AAK52908 BAC32718 BAC33040 BAC34375 EDL14550

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca