InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cad

Summary

InnateDB Protein

IDBP-147146.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Cad

Protein Name

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Synonyms

2410008J01Rik; AU018859; Cpad;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013773

InnateDB Gene

IDBG-147144 (Cad)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004070	aspartate carbamoyltransferase activity
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151	dihydroorotase activity
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016597	amino acid binding
GO:0016743	carboxyl- or carbamoyltransferase activity
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001889	liver development
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006520	cellular amino acid metabolic process
GO:0006541	glutamine metabolic process
GO:0006543	glutamine catabolic process
GO:0006807	nitrogen compound metabolic process
GO:0007507	heart development
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008152	metabolic process
GO:0009790	embryo development
GO:0014075	response to amine
GO:0017144	drug metabolic process
GO:0031000	response to caffeine
GO:0031100	organ regeneration
GO:0033574	response to testosterone
GO:0035690	cellular response to drug
GO:0044205	'de novo' UMP biosynthetic process
GO:0051414	response to cortisol
GO:0070409	carbamoyl phosphate biosynthetic process
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1916969

InterPro

IPR002082 Aspartate carbamoyltransferase
IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain
IPR006130 Aspartate/ornithine carbamoyltransferase
IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
IPR006274 Carbamoyl-phosphate synthase, small subunit
IPR006275 Carbamoyl-phosphate synthase, large subunit
IPR006680 Amidohydrolase 1
IPR011059 Metal-dependent hydrolase, composite domain
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011607 Methylglyoxal synthase-like domain
IPR011761 ATP-grasp fold
IPR016185 Pre-ATP-grasp domain
IPR017926 Glutamine amidotransferase
IPR029062 Class I glutamine amidotransferase-like

PFAM