InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: P2ry12

Summary

InnateDB Protein

IDBP-147154.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2ry12

Protein Name

purinergic receptor P2Y, G-protein coupled 12

Synonyms

2900079B22Rik; 4921504D23Rik; P2Y12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051353

InnateDB Gene

IDBG-147152 (P2ry12)

Protein Structure

UniProt Annotation

Function

Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation. {ECO:0000269PubMed:12897207}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0001621	ADP receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0010700	negative regulation of norepinephrine secretion
GO:0030030	cell projection organization
GO:0030168	platelet activation
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0043270	positive regulation of ion transport
GO:0043491	protein kinase B signaling
GO:0045596	negative regulation of cell differentiation
GO:0051924	regulation of calcium ion transport
GO:0070527	platelet aggregation
GO:0070588	calcium ion transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009897	external side of plasma membrane
GO:0009925	basal plasma membrane
GO:0016021	integral component of membrane
GO:0031224	intrinsic component of membrane

Protein Structure and Domains

PDB ID

MGI:1918089

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR005394 P2Y12 purinoceptor
IPR005466 P2Y14 purinoceptor
IPR008109 P2Y13 purinoceptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01569
PR01655
PR01735

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CPV9