Version 5.4
Mus musculus Protein: Jkamp
Summary
InnateDB Protein IDBP-147263.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Jkamp
Protein Name JNK1/MAPK8-associated membrane protein
Synonyms 1200003C05Rik; 2310047L11Rik; Jamp;
Species Mus musculus
Ensembl Protein ENSMUSP00000061370
InnateDB Gene IDBG-147261 (Jkamp)
Protein Structure
UniProt Annotation
Function May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system. {ECO:0000269PubMed:16166642}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:16166642, ECO:0000269PubMed:18784250}; Multi- pass membrane protein {ECO:0000269PubMed:16166642, ECO:0000269PubMed:18784250}.
Disease Associations
Tissue Specificity Expressed in numerous tissues, including brain, spleen, thymus, liver, kidney and testis. Elevated expression in medulloblastoma. {ECO:0000269PubMed:16166642}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006986 response to unfolded protein
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915057
InterPro IPR008485 Protein of unknown function DUF766
PFAM PF05571
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BI36
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 104771
UniGene Mm.258935
RefSeq NP_077167
MGI ID
MGI Symbol Jkamp
OMIM
CCDS CCDS25967
HPRD
IMGT
EMBL AK004555 AK013502 BC002238 CR974486
GenPept AAH02238 BAB28884 BAC25088 CAX15360 CAX15361

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca