InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sohlh1

Summary

InnateDB Protein

IDBP-147266.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sohlh1

Protein Name

spermatogenesis and oogenesis specific basic helix-loop-helix 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076253

InnateDB Gene

IDBG-147264 (Sohlh1)

Protein Structure

UniProt Annotation

Function

Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development. {ECO:0000269PubMed:16564520, ECO:0000269PubMed:16690745}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16690745}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:16690745}.

Disease Associations

Tissue Specificity

In males, it is mainly expressed in testis, while in females it is mainly expressed in ovary. In testis, it is exclusively expressed in spermatogonia, with a preference for prespermatogonia and type A spermatogonia. In ovary, it is detected in germ cell cysts, primordial follicles, and primary follicles but is undetectable by the secondary follicle stage (at protein level). {ECO:0000269PubMed:16564520, ECO:0000269PubMed:16690745}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001541	ovarian follicle development
GO:0006351	transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0010468	regulation of gene expression
GO:0030154	cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048477	oogenesis