InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfe2l3

Summary

InnateDB Protein

IDBP-147293.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfe2l3

Protein Name

nuclear factor, erythroid derived 2, like 3

Synonyms

Nrf3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005103

InnateDB Gene

IDBG-147291 (Nfe2l3)

Protein Structure

UniProt Annotation

Function

Activates erythroid-specific, globin gene expression.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}.

Disease Associations

Tissue Specificity

High level expression in brain, thymus, testis and placenta. Medium level expression in uterus, stomach and lung. Low level expression in kidney. No expression in heart, liver, spleen and ovary. {ECO:0000269PubMed:15060151}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated