InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdcl3

Summary

InnateDB Protein

IDBP-147301.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdcl3

Protein Name

phosducin-like 3

Synonyms

1110061A19Rik; C80025; Viaf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027247

InnateDB Gene

IDBG-147299 (Pdcl3)

Protein Structure

UniProt Annotation

Function

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0044183	protein binding involved in protein folding

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006457	protein folding
GO:0006915	apoptotic process
GO:0045766	positive regulation of angiogenesis
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1916083

InterPro

IPR006442 Type II toxin-antitoxin system, antitoxin Phd/YefM
IPR012336 Thioredoxin-like fold
IPR024253 Phosducin, thioredoxin-like domain

PFAM

PF02604
PF13098
PF13192
PF13462
PF13905
PF02114

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BVF2

PhosphoSite

PhosphoSite-Q8BVF2

TrEMBL

UniProt Splice Variant

Entrez Gene

68833

UniGene

RefSeq

NP_081126

MGI ID

MGI Symbol

Pdcl3

OMIM

CCDS

CCDS14903

HPRD

IMGT

EMBL

AF110512 AK004334 AK078372 AK168509 BC005601

GenPept

AAG21888 AAH05601 BAB23267 BAC37242 BAE40392