InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pkd1

Summary

InnateDB Protein

IDBP-147325.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pkd1

Protein Name

polycystic kidney disease 1 homolog

Synonyms

mFLJ00285; PC1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049296

InnateDB Gene

IDBG-147323 (Pkd1)

Protein Structure

UniProt Annotation

Function

Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein- protein and protein-carbohydrate. {ECO:0000269PubMed:12514735, ECO:0000269PubMed:20096584}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium {ECO:0000269PubMed:12514735}. Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autocatalytic cleavage at the GPS domain. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030246	carbohydrate binding
GO:0044325	ion channel binding

Biological Process

GO:0001502	cartilage condensation
GO:0001568	blood vessel development
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0006611	protein export from nucleus
GO:0006807	nitrogen compound metabolic process
GO:0006816	calcium ion transport
GO:0007050	cell cycle arrest
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007259	JAK-STAT cascade
GO:0007507	heart development
GO:0016337	single organismal cell-cell adhesion
GO:0018105	peptidyl-serine phosphorylation
GO:0021510	spinal cord development
GO:0021915	neural tube development
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032092	positive regulation of protein binding
GO:0034405	response to fluid shear stress
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0043588	skin development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048806	genitalia development
GO:0050982	detection of mechanical stimulus
GO:0051216	cartilage development
GO:0060236	regulation of mitotic spindle organization
GO:0060428	lung epithelium development
GO:0060674	placenta blood vessel development
GO:0061136	regulation of proteasomal protein catabolic process
GO:0070588	calcium ion transmembrane transport
GO:0072001	renal system development
GO:0072164	mesonephric tubule development
GO:0072177	mesonephric duct development
GO:0072205	metanephric collecting duct development
GO:0072218	metanephric ascending thin limb development
GO:0072237	metanephric proximal tubule development
GO:0072287	metanephric distal tubule morphogenesis

Cellular Component

GO:0002133	polycystin complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0031512	motile primary cilium
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97603

InterPro

IPR000203 GPS motif
IPR000372 Leucine-rich repeat-containing N-terminal
IPR000434 Polycystic kidney disease type 1 protein
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000601 PKD domain
IPR001024 PLAT/LH2 domain
IPR001304 C-type lectin
IPR002859 PKD/REJ-like protein
IPR002889 Carbohydrate-binding WSC
IPR003591 Leucine-rich repeat, typical subtype
IPR006228 Polycystin cation channel
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR013994 Carbohydrate-binding WSC, subgroup
IPR014010 Egg jelly receptor, REJ-like
IPR016187 C-type lectin fold
IPR022409 PKD/Chitinase domain

PFAM