InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Npas2

Summary

InnateDB Protein

IDBP-147369.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npas2

Protein Name

neuronal PAS domain protein 2

Synonyms

bHLHe9; MOP4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054719

InnateDB Gene

IDBG-147367 (Npas2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity
GO:0051879	Hsp90 protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0042745	circadian sleep/wake cycle
GO:0045475	locomotor rhythm
GO:0045739	positive regulation of DNA repair
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051775	response to redox state
GO:0060548	negative regulation of cell death
GO:2001020	regulation of response to DNA damage stimulus

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:109232

InterPro

IPR000014 PAS domain
IPR001067 Nuclear translocator
IPR001610 PAC motif
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold

PFAM

PF13188
PF13426
PF00010
PF08447
PF00989

PRINTS

PR00785

PIRSF

SMART

SM00091
SM00086
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt