Version 5.4
Mus musculus Protein: Ccdc8
Summary
InnateDB Protein IDBP-147395.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccdc8
Protein Name coiled-coil domain containing 8
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000092399
InnateDB Gene IDBG-147393 (Ccdc8)
Protein Structure
UniProt Annotation
Function Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0007088 regulation of mitosis
GO:0010923 negative regulation of phosphatase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:1990393 3M complex
Protein Structure and Domains
PDB ID MGI:3612184
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt D3YZV8
PhosphoSite PhosphoSite-NP_001095005
TrEMBL
UniProt Splice Variant
Entrez Gene 434130
UniGene Mm.484826
RefSeq NP_001095005
MGI ID
MGI Symbol Ccdc8
OMIM
CCDS CCDS52044
HPRD
IMGT
EMBL AC148976 CH466654
GenPept EDL42062

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca