InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fli1

Summary

InnateDB Protein

IDBP-147471.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fli1

Protein Name

Friend leukemia integration 1

Synonyms

EWSR2; Fli-1; SIC-1; Sic1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016231

InnateDB Gene

IDBG-147469 (Fli1)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Subcellular Localization

Nucleus.

Disease Associations

Note=Involved in erythroleukemia induction by Friend murine leukemia virus (F-MULV).

Tissue Specificity

Expressed in both hematopoietic and nonhematopoietic tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	2 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008015	blood circulation
GO:0009887	organ morphogenesis
GO:0009987	cellular process
GO:0035855	megakaryocyte development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter