InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map3k13

Summary

InnateDB Protein

IDBP-147517.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k13

Protein Name

mitogen-activated protein kinase kinase kinase 13

Synonyms

C130026N12Rik; LZK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047388

InnateDB Gene

IDBG-147515 (Map3k13)

Protein Structure

UniProt Annotation

Function

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0007254	JNK cascade
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0008385	IkappaB kinase complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2444243

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017419 Mitogen-activated protein kinase kinase kinase, 12/13
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

PIRSF038165

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References