InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc30a3

Summary

InnateDB Protein

IDBP-147529.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc30a3

Protein Name

solute carrier family 30 (zinc transporter), member 3

Synonyms

Znt3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031037

InnateDB Gene

IDBG-147527 (Slc30a3)

Protein Structure

UniProt Annotation

Function

Involved in accumulation of zinc in synaptic vesicles.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305PubMed:21998198}; Multi- pass membrane protein {ECO:0000305PubMed:21998198}. Cell junction, synapse, synaptosome {ECO:0000269PubMed:21998198}.

Disease Associations

Tissue Specificity

Brain and testis. In the brain, most abundant in hippocampus and cerebral cortex. In the testis, expression is restricted to germ cells and is highest in pachytene spermatocytes and round spermatids.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008324	cation transmembrane transporter activity

Biological Process

GO:0006812	cation transport
GO:0006829	zinc ion transport
GO:0010312	detoxification of zinc ion
GO:0032119	sequestering of zinc ion
GO:0051050	positive regulation of transport
GO:0055085	transmembrane transport
GO:0061088	regulation of sequestering of zinc ion

Cellular Component

GO:0005737	cytoplasm
GO:0005770	late endosome
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0043005	neuron projection