InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr2e1

Summary

InnateDB Protein

IDBP-147575.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr2e1

Protein Name

nuclear receptor subfamily 2, group E, member 1

Synonyms

fierce; frc; Mtl1; Mtll; tailless; TLL; Tlx; XTLL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019938

InnateDB Gene

IDBG-147573 (Nr2e1)

Protein Structure

UniProt Annotation

Function

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Regulates cell cycle progression in neural stem cells of rhe developing brain. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acid receptor (RAR) regulation in retinal cells. {ECO:0000250, ECO:0000269PubMed:10706625, ECO:0000269PubMed:16702404, ECO:0000269PubMed:17901127}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407, ECO:0000269PubMed:17901127}.

Disease Associations

Tissue Specificity

Expressed in embryonic developing forebrain and in dorsal midbrain. Outside the neural epithelium only found in the surface ectoderm at the site of nasal placode formation, where subsequently the nasal and olfactory epithelium is formed. Also expressed in adult brain. {ECO:0000269PubMed:7720587}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001662	behavioral fear response
GO:0002118	aggressive behavior
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0007601	visual perception
GO:0008284	positive regulation of cell proliferation
GO:0008347	glial cell migration
GO:0021542	dentate gyrus development
GO:0021764	amygdala development
GO:0021772	olfactory bulb development
GO:0021819	layer formation in cerebral cortex
GO:0021872	forebrain generation of neurons
GO:0021895	cerebral cortex neuron differentiation
GO:0021960	anterior commissure morphogenesis
GO:0021987	cerebral cortex development
GO:0030198	extracellular matrix organization
GO:0035019	somatic stem cell maintenance
GO:0035176	social behavior
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0045165	cell fate commitment
GO:0045665	negative regulation of neuron differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045787	positive regulation of cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048712	negative regulation of astrocyte differentiation
GO:0048814	regulation of dendrite morphogenesis
GO:0051128	regulation of cellular component organization
GO:0060041	retina development in camera-type eye
GO:0060164	regulation of timing of neuron differentiation
GO:0060291	long-term synaptic potentiation
GO:0090049	regulation of cell migration involved in sprouting angiogenesis
GO:2000178	negative regulation of neural precursor cell proliferation
GO:2000179	positive regulation of neural precursor cell proliferation
GO:2000648	positive regulation of stem cell proliferation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1100526

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt