InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Liph

Summary

InnateDB Protein

IDBP-147623.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Liph

Protein Name

lipase, member H

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073853

InnateDB Gene

IDBG-147619 (Liph)

Protein Structure

UniProt Annotation

Function

Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA). {ECO:0000250}.

Subcellular Localization

Secreted. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in placenta and colon. Weakly expressed in small intestine. {ECO:0000269PubMed:12213196}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0008201	heparin binding

Biological Process

GO:0016042

lipid catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:2388029

InterPro

IPR000734 Lipase
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00151

PRINTS

PR00821

PIRSF

PIRSF000865

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt