InnateDB Protein
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IDBP-147703.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Senp2
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Protein Name
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SUMO/sentrin specific peptidase 2
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Synonyms
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2310007L05Rik; 4930538C18Rik; AI646780; AW554757; mKIAA1331; Smt3ip2; SuPr-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023561
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InnateDB Gene
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IDBG-147701 (Senp2)
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Protein Structure
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Function |
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1 (By similarity). Isoform 3 activates transcription. {ECO:0000250, ECO:0000269PubMed:11489887, ECO:0000269PubMed:12419228}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12419228}.Isoform 1: Nucleus, nuclear pore complex. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}.Isoform 2: Cytoplasm. Cytoplasmic vesicle. Note=Found in the cytoplasm and in cytoplasmic vesicles, together with axin.Isoform 3: Nucleus, PML body.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis. Detected in brain, heart and thymus. {ECO:0000269PubMed:12419228}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1923076
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InterPro |
IPR003653
Peptidase C48, SUMO/Sentrin/Ubl1
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PFAM |
PF02902
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q91ZX6
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PhosphoSite |
PhosphoSite-Q91ZX6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
75826
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UniGene |
Mm.403056
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RefSeq |
NP_083733
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MGI ID |
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MGI Symbol |
Senp2
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OMIM |
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CCDS |
CCDS28065
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HPRD |
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IMGT |
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EMBL |
AF368904
AK015987
AK031030
AY188288
BC031652
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GenPept |
AAH31652
AAL14437
AAO27902
BAB30067
BAC27222
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