Version 5.4
Mus musculus Protein: Rnf149
Summary
InnateDB Protein IDBP-147733.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf149
Protein Name ring finger protein 149
Synonyms 1600023E10Rik; AV037261; C76763; Gm15832; Greul4; OTTMUSG00000026591;
Species Mus musculus
Ensembl Protein ENSMUSP00000050388
InnateDB Gene IDBG-147731 (Rnf149)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0031647 regulation of protein stability
GO:0035690 cellular response to drug
GO:0043409 negative regulation of MAPK cascade
Cellular Component
GO:0005575 cellular_component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2677438
InterPro IPR001841 Zinc finger, RING-type
IPR003137 Protease-associated domain, PA
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF02225
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U2C5
PhosphoSite PhosphoSite-Q3U2C5
TrEMBL
UniProt Splice Variant
Entrez Gene 67702
UniGene Mm.28614
RefSeq NP_001028307
MGI ID
MGI Symbol Rnf149
OMIM
CCDS CCDS14907
HPRD
IMGT
EMBL AC119809 AK155360 AY155439 BC115968
GenPept AAI15969 AAN75220 BAE33216

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca