Version 5.4
Mus musculus Protein: Gtf3c2
Summary
InnateDB Protein IDBP-147769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gtf3c2
Protein Name general transcription factor IIIC, polypeptide 2, beta
Synonyms 1300004C11Rik; 2610510G03Rik; AI225816; AU041069; mKIAA0011; TFIIIC110;
Species Mus musculus
Ensembl Protein ENSMUSP00000085325
InnateDB Gene IDBG-147761 (Gtf3c2)
Protein Structure
UniProt Annotation
Function Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006383 transcription from RNA polymerase III promoter
Cellular Component
GO:0000127 transcription factor TFIIIC complex
Protein Structure and Domains
PDB ID MGI:1919002
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BL74
PhosphoSite PhosphoSite-Q8BL74
TrEMBL D3YY96
UniProt Splice Variant
Entrez Gene 71752
UniGene Mm.473305
RefSeq NP_082177
MGI ID
MGI Symbol Gtf3c2
OMIM
CCDS CCDS39053
HPRD
IMGT
EMBL AC109608 AC114619 AK008582 AK012095 AK043944 AK046192 AK083636 AK129033 AK151300 AK152439 BC034369
GenPept AAH34369 BAB25760 BAB28026 BAC31709 BAC32629 BAC38975 BAC97843 BAE30283 BAE31220

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca