InnateDB Protein
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IDBP-147825.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Phax
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Protein Name
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phosphorylated adaptor for RNA export
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Synonyms
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2810055C14Rik; 4933427L19Rik; AU018701; AU018854; D18Ertd65e; p55; Rnuxa;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000008445
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InnateDB Gene
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IDBG-147823 (Phax)
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Protein Structure
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Function |
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation- independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)- capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:10786834}. Note=Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
20 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1891839
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InterPro |
IPR019385
Phosphorylated adapter RNA export protein, RNA-binding domain
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PFAM |
PF10258
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JJT9
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PhosphoSite |
PhosphoSite-Q9JJT9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56698
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UniGene |
Mm.214569
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RefSeq |
NP_064380
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MGI ID |
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MGI Symbol |
Phax
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OMIM |
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CCDS |
CCDS29259
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HPRD |
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IMGT |
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EMBL |
AJ276504
AK030749
BC049590
BC061110
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GenPept |
AAH49590
AAH61110
BAC27117
CAB87994
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