InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hoxa4

Summary

InnateDB Protein

IDBP-147851.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxa4

Protein Name

homeobox A4

Synonyms

AV206827; Hox-1.4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098943

InnateDB Gene

IDBG-147849 (Hoxa4)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT- 3'.

Subcellular Localization

Nucleus.

Disease Associations

Note=Overexpression results in abnormal gut development (megacolon).

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0009952	anterior/posterior pattern specification
GO:0048704	embryonic skeletal system morphogenesis