InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prrxl1

Summary

InnateDB Protein

IDBP-147920.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prrxl1

Protein Name

paired related homeobox protein-like 1

Synonyms

Drg11; Drgx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064107

InnateDB Gene

IDBG-147918 (Prrxl1)

Protein Structure

UniProt Annotation

Function

Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. {ECO:0000269PubMed:11498051}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:P54821, ECO:0000255PROSITE-ProRule:PRU00108, ECO:0000255PROSITE- ProRule:PRU00138}.

Disease Associations

Tissue Specificity

Expressed in the dorsal horn of the spinal cord and dorsal root ganglia. Isoform 1 is higher expressed than isoform 2 both in the dorsal root ganglia and in the spinal cord. Isoform 2 is exclusively localized in neurons primarily involved in the processing of the pain somatosensory modality. {ECO:0000269PubMed:11498051, ECO:0000269PubMed:19598127}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0009593	detection of chemical stimulus
GO:0016048	detection of temperature stimulus
GO:0021516	dorsal spinal cord development
GO:0021559	trigeminal nerve development
GO:0030182	neuron differentiation
GO:0050954	sensory perception of mechanical stimulus

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:2148204

InterPro

IPR001356 Homeobox domain
IPR009057 Homeodomain-like

PFAM

PF00046

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BYH0

PhosphoSite

PhosphoSite-Q8BYH0

TrEMBL

UniProt Splice Variant

Entrez Gene

107751

UniGene

RefSeq

NP_001001796

MGI ID

MGI Symbol

Prrxl1

OMIM

CCDS

CCDS26922

HPRD

IMGT

EMBL

AK039633 AY116506 BC132613 BC145917 EU670677 EU670678

GenPept

AAI32614 AAI45918 AAM49062 ACD45984 ACD45985 BAC30405