InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: N4BP2

Summary

InnateDB Protein

IDBP-14801.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

N4BP2

Protein Name

NEDD4 binding protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261435

InnateDB Gene

IDBG-14797 (N4BP2)

Protein Structure

UniProt Annotation

Function

Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269PubMed:12730195}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity

Biological Process

GO:0016310	phosphorylation
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002625 Smr protein/MutS2 C-terminal
IPR003892 Ubiquitin system component Cue
IPR009060 UBA-like
IPR013899 Domain of unknown function DUF1771
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01713
PF02845
PF08590

PRINTS

PIRSF

SMART

SM00463
SM00546

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86UW6