InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dcps

Summary

InnateDB Protein

IDBP-148038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dcps

Protein Name

decapping enzyme, scavenger

Synonyms

1700001E16Rik; AA408441;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034539

InnateDB Gene

IDBG-148036 (Dcps)

Protein Structure

UniProt Annotation

Function

Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000340	RNA 7-methylguanosine cap binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0050072	m7G(5')pppN diphosphatase activity

Biological Process

GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0036245	cellular response to menadione
GO:0043069	negative regulation of programmed cell death
GO:0045292	mRNA cis splicing, via spliceosome