InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF9

Summary

InnateDB Protein

IDBP-14812.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF9

Protein Name

fibroblast growth factor 9 (glia-activating factor)

Synonyms

FGF-9; GAF; HBFG-9; HBGF-9; SYNS3;

Species

Homo sapiens

Ensembl Protein

ENSP00000371790

InnateDB Gene

IDBG-14810 (FGF9)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. {ECO:0000269PubMed:16597617, ECO:0000269PubMed:8663044}.

Subcellular Localization

Secreted.

Disease Associations

Multiple synostoses syndrome 3 (SYNS3) [MIM:612961]: A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism. {ECO:0000269PubMed:19589401}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Glial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001649	osteoblast differentiation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002062	chondrocyte differentiation
GO:0006606	protein import into nucleus
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008584	male gonad development
GO:0010628	positive regulation of gene expression
GO:0021762	substantia nigra development
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030238	male sex determination
GO:0030324	lung development
GO:0030326	embryonic limb morphogenesis
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042472	inner ear morphogenesis
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response
GO:0045880	positive regulation of smoothened signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048505	regulation of timing of cell differentiation
GO:0048566	embryonic digestive tract development
GO:0048706	embryonic skeletal system development
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051781	positive regulation of cell division
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060484	lung-associated mesenchyme development
GO:0090263	positive regulation of canonical Wnt signaling pathway