InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Six4

Summary

InnateDB Protein

IDBP-148185.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Six4

Protein Name

sine oculis-related homeobox 4 homolog (Drosophila)

Synonyms

AI047561; AREC3; TrexBF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036150

InnateDB Gene

IDBG-148183 (Six4)

Protein Structure

UniProt Annotation

Function

Involved in skeletal muscle development. Also implicated in retina and kidney development.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Mainly expressed in the skeletal muscle (isoform 1 and isoform 2 but not isoform 3), and weakly in the heart. Also found in the retina and the distal tube of kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007519	skeletal muscle tissue development
GO:0008582	regulation of synaptic growth at neuromuscular junction
GO:0010468	regulation of gene expression
GO:0032880	regulation of protein localization
GO:0042472	inner ear morphogenesis
GO:0043524	negative regulation of neuron apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048538	thymus development
GO:0048699	generation of neurons
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0048856	anatomical structure development
GO:0051451	myoblast migration
GO:0072075	metanephric mesenchyme development
GO:0072095	regulation of branch elongation involved in ureteric bud branching
GO:0072107	positive regulation of ureteric bud formation
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis